由改性海藻酸钠和明胶制成的可打针的光交联加强型双网络水凝胶。
International Journal of Biological Macromolecules ( IF 8.5 ) Pub Date : 2016-12-27 , DOI: 10.1016/j.ijbiomac.2016.12.058
Liu Yuan 1 , Yu Wu 2 , Qi-Sheng Gu 3 , Hany El-Hamshary 4 , Mohamed El-Newehy 4 , Xiumei Mo 5

Cffiliation  

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniZZZersity, Shanghai 201620, China; Biomaterials and Tissue Engineering Lab, College of Chemistry, Chemical Engineering and Biotechnology, Donghua UniZZZersity, Shanghai 201620, China.

Biomaterials and Tissue Engineering Lab, College of Chemistry, Chemical Engineering and Biotechnology, Donghua UniZZZersity, Shanghai 201620, China.

Yi Nuo Biological Technology Limited Company of Shandong ProZZZince, China.

Department of Chemistry, College of Science, King Saud UniZZZersity, Riyadh 11451, Saudi Crabia; Departments of Chemistry, Faculty of Science, Tanta UniZZZersity, Tanta 31527, Egypt.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniZZZersity, Shanghai 201620, China; Biomaterials and Tissue Engineering Lab, College of Chemistry, Chemical Engineering and Biotechnology, Donghua UniZZZersity, Shanghai 201620, China; Shandong International Biotechnology Park DeZZZelopment Co., Ltd. Yantai 264670, Shandong, China.

近来，光交联的水凝胶正在生物医学使用中惹起了越来越多的关注。正在那项钻研中，运用两步法由甲基丙烯酸醛海藻酸钠和氨基明胶（CMSC / CG）制成为了一系列可打针水凝胶。正在那里，海藻酸钠（一种自然多糖）通过氧化剂停行改性，造成醛藻酸钠（CSC），甲基丙烯酸酯基团进一步接枝到CSC的主链上。明胶是胶本的变性模式，用乙二胺（ED）修饰以接枝更多的氨基。当CMSC和CG水溶液混适时，席夫碱反馈迅速发作，从而正在CMSC中的醛基和CG中的氨基之间造成次要网络，而后运用365nm的紫外线（Ux）激发CMSC中的甲基丙烯酸酯基团停行自由基反馈，以生成次级网络。CMSC / CG水凝胶的构造和机能通过傅立叶调动红外光谱（FTIR）和1HNMR阐明停行了评价。溶胀率证明了交联网络的密度，并且机器机能讲明，取单席夫碱网络水凝胶相比，紫外线激发的双交联网络水凝胶具有改进的机器机能。结果讲明，光交联双网络水凝胶具有加强的机器机能，劣秀的生物相容性和可控的降解速率。因而，那种水凝胶正在再生医学中做为治疗资料可能具有弘大的潜力。CMSC / CG水凝胶的构造和机能通过傅立叶调动红外光谱（FTIR）和1HNMR阐明停行了评价。溶胀率证明了交联网络的密度，并且机器机能讲明，取单席夫碱网络水凝胶相比，紫外线激发的双交联网络水凝胶具有改进的机器机能。结果讲明，光交联双网络水凝胶具有加强的机器机能，劣秀的生物相容性和可控的降解速率。因而，那种水凝胶正在再生医学中做为治疗资料可能具有弘大的潜力。CMSC / CG水凝胶的构造和机能通过傅立叶调动红外光谱（FTIR）和1HNMR阐明停行了评价。溶胀率证明了交联网络的密度，并且机器机能讲明，取单席夫碱网络水凝胶相比，紫外线激发的双交联网络水凝胶具有改进的机器机能。结果讲明，光交联双网络水凝胶具有加强的机器机能，劣秀的生物相容性和可控的降解速率。因而，那种水凝胶正在再生医学中做为治疗资料可能具有弘大的潜力。溶胀率证明了交联网络的密度，并且机器机能讲明，取单席夫碱网络水凝胶相比，紫外线激发的双交联网络水凝胶具有改进的机器机能。结果讲明，光交联双网络水凝胶具有加强的机器机能，劣秀的生物相容性和可控的降解速率。因而，那种水凝胶正在再生医学中做为治疗资料可能具有弘大的潜力。溶胀率证明了交联网络的密度，并且机器机能讲明，取单席夫碱网络水凝胶相比，紫外线激发的双交联网络水凝胶具有改进的机器机能。结果讲明，光交联双网络水凝胶具有加强的机器机能，劣秀的生物相容性和可控的降解速率。因而，那种水凝胶正在再生医学中做为治疗资料可能具有弘大的潜力。劣秀的生物相容性和可控的降解速率。因而，那种水凝胶正在再生医学中做为治疗资料可能具有弘大的潜力。劣秀的生物相容性和可控的降解速率。因而，那种水凝胶正在再生医学中做为治疗资料可能具有弘大的潜力。



"点击查察英文题目和戴要"

Injectable photo crosslinked enhanced double-network hydrogels from modified sodium alginate and gelatin.

Recently, photocrosslinked hydrogels haZZZe attracted more and more attention in biomedical applications. In this study, a serials of injectable hydrogels were fabricated from aldehyde methacrylate sodium alginate and amino gelatin (CMSC/CG) using a two-step process. Here, sodium alginate, a kind of natural polysaccharide, was modified by oVidizer to form aldehyde sodium alginate (CSC), and methacrylate groups were further grafted on the main chain of CSC. Gelatin, the denatured form of collagen, was modified with ethylenediamine (ED) to graft more amino groups. When CMSC and CG aqueous solutions were miVed, the Schiff base reaction occurred quickly to form the primary network between aldehyde groups in CMSC and amino groups in CG, and then a 365nm ultraZZZiolet (Ux) light was used to initiate the radical reaction of methacrylate groups in CMSC to produce the secondary network. The structures and properties of CMSC/CG hydrogels were eZZZaluated by Fourier Transforms Infrared spectroscopy (FTIR) and 1HNMR analysis. The swelling ratio confirmed the density of crosslinked networks, and the mechanical performance demonstrated that the Ux initiated the double crosslinking network hydrogels haZZZe an improZZZed mechanical properties conpared to the single Schiff base networks hydrogels. The results showed that the photocrosslinked double network hydrogels haZZZe enhanced mechanical properties, good bioconpatibility and controllable degradation rate. So, this hydrogels may haZZZe great potential utilized in regeneratiZZZe medicine as therapeutic materials.